Product Description: Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent[1][2].
Applications: Cancer-programmed cell death
Formula: C24H35NO5
References: [1]Choo SJ, et al., Aspochalasin I, a melanogenesis inhibitor from Aspergillus sp. J Microbiol Biotechnol. 2009 Apr;19(4):368-71/[2]Zhou GX, et al., Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32.
CAS Number: 670225-69-1
Molecular Weight: 417.54
Research Area: Cancer
Target: Tyrosinase