Brevilin A, CAS 16503-32-5

Product Description: Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC50=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy[1][2].

Applications: Cancer-Kinase/protease

Formula: C20H26O5

References: [1]Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697./[2]You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.

CAS Number: 16503-32-5

Molecular Weight: 346.42

Compound Purity: 99.81

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;JAK;STAT

• SKU: MEXHY-N2959-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N2959-25
• Package Unit: 25 mg
• Quantity Unit: STK