Product Description: Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper[1]. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc[2].
Applications: COVID-19-immunoregulation
Formula: C30H38O13
References: [1]Seung Mok Ryu, et al. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus Res. 2017 Jan 2;227:49-56./[2]Ning Wei, et al. Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene. 2019 Mar;38(10):1676-1687.
CAS Number: 53729-52-5
Molecular Weight: 606.61
Compound Purity: 98.89
Research Area: Cancer; Infection
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: STAT
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