Product Description: Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage[1][2][3][4].
Applications: Neuroscience-Neurodegeneration
Formula: C26H28O6
References: [1]Rea KA, et al. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug;164:162-171./[2]Eggers C, et al. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Nov;169:113609./[3]Tomko AM, et al. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer. J Cannabis Res. 2022 Jul 22;4(1):41./[4]Puopolo T, et al. Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase. Biology (Basel). 2022 Sep 28;11(10):1416.
CAS Number: 76735-57-4
Molecular Weight: 436.50
Compound Purity: 98.46
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Amyloid-β;Apoptosis
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