Chaetominine, CAS 918659-56-0

Product Description: Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells[1][2].

Applications: Cancer-Kinase/protease

Formula: C22H18N4O4

References: [1]Jiao RH, et al. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Org Lett./[2]Yao J, et al. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochem Biophys Res Commun. 2016;473(4):867-873.

CAS Number: 918659-56-0

Molecular Weight: 402.40

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Akt;Keap1-Nrf2;PI3K

• SKU: MEXHY-125136-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125136-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK