Product Description: Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].
Applications: COVID-19-immunoregulation
Formula: C7H4O6
References: [1]Shin HJ, et al. Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Immunopharmacol Immunotoxicol. 2011 Dec;33(4):614-9./[2]Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50./[3]Oh HA, et al. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Send to Int Immunopharmacol. 2011 Jan;11(1):39-45.
CAS Number: 99-32-1
Molecular Weight: 184.10
Compound Purity: 99.91
Research Area: Inflammation/Immunology; Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 2.5 mg/mL (ultrasonic)
Target: Caspase;NF-κB
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