Product Description: Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α[1].
Applications: COVID-19-immunoregulation
Formula: C17H18O4
References: [1]Shaoxia Ye, et al. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019 Oct 16;24(20):3731.
CAS Number: 1449382-91-5
Molecular Weight: 286.32
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: NF-κB;Reactive Oxygen Species;Toll-like Receptor (TLR)
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