Coelonin, CAS 82344-82-9

Product Description: Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2].

Formula: C15H14O3

References: [1]Jiang F, et al. Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 8;20(18):4422./[2]Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021 Apr 5;896:173931.

CAS Number: 82344-82-9

Molecular Weight: 242.27

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Akt;Interleukin Related;NF-κB;PTEN;TNF Receptor

• SKU: MEXHY-N8884-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N8884-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK