Product Description: Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells[1].
Applications: Cancer-programmed cell death
Formula: C53H78O17
References: [1]Bishayee K, et al. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Mol Cell Biochem. 2013 Oct;382(1-2):173-83.
CAS Number: 11051-90-4
Molecular Weight: 987.18
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;MDM-2/p53;Reactive Oxygen Species