Product Description: Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases[1][2][3][4][5].
Formula: C10H12N2O
References: [1]Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug;5(4):473-83./[2]Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb;50(2):128-36./[3]Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-)-cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137(3): 313-318./[4]Dwoskin L P, et al. (S)-(−)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288(3): 905-911./[5]Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.
CAS Number: 486-56-6
Molecular Weight: 176.22
Compound Purity: 99.56
Research Area: Inflammation/Immunology; Cardiovascular Disease
Solubility: DMSO : 65 mg/mL (ultrasonic)/Ethanol : 120 mg/mL (ultrasonic)
Target: Endogenous Metabolite;nAChR
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