Product Description: Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3].
Applications: COVID-19-immunoregulation
Formula: C27H44O7
References: [1]Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645./[2]Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9./[3]Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.
CAS Number: 5289-74-7
Molecular Weight: 480.63
Compound Purity: 99.63
Research Area: Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Autophagy;Caspase;Endogenous Metabolite
English
Deutsch
