Product Description: Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC50 of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities[1][2][3][4].
Applications: Cancer-programmed cell death
Formula: C6H10S2
References: [1]Gupta N, et al. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131(6):1662-1667. /[2]You-Sheng Huang, et al. Diallyl disulfide inhibits the proliferation of HT-29 human colon cancer cells by inducing differentially expressed genes. Mol Med Rep. 2011 May-Jun;4(3):553-9./[3]Xiaoyou Wei, et al. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation. 2021 Aug;44(4):1381-1395./[4]Aline de Oliveira Pontes Cardoso, et al. Diallyl disulfide prevents cigarette smoke-induced emphysema in mice. Pulm Pharmacol Ther. 2021 Aug:69:102053.
CAS Number: 2179-57-9
Molecular Weight: 146.27
Compound Purity: 99.36
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Others
English
Deutsch
