Product Description: Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C38H34O16
References: [1]Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400./[2]Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73.
CAS Number: 875313-64-7
Molecular Weight: 746.67
Compound Purity: 99.28
Research Area: Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Sodium Channel
English
Deutsch
