Ent-(+)-Verticilide, CAS 2056011-05-1

Product Description: ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1].

Formula: C44H76N4O12

References: [1]Suzanne M Batiste, et al. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815.

CAS Number: 2056011-05-1

Molecular Weight: 853.09

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Calcium Channel

• SKU: MEXHY-N7491A-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N7491A-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK