Product Description: Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].
Applications: Cancer-Kinase/protease
Formula: C30H48O5
References: [1]Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200./[2]Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098.
CAS Number: 53155-25-2
Molecular Weight: 488.70
Compound Purity: 98.34
Research Area: Cancer
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Apoptosis;DNA/RNA Synthesis;PI3K
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