Fraxinellone, CAS 28808-62-0

Product Description: Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1[1].

Applications: Cancer-Kinase/protease

Formula: C14H16O3

References: [1]Xing Y, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018 Sep;135:166-180.

CAS Number: 28808-62-0

Molecular Weight: 232.28

Compound Purity: 99.99

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HIF/HIF Prolyl-Hydroxylase;PD-1/PD-L1;STAT

• SKU: MEXHY-N0242-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N0242-50
• Package Unit: 50 mg
• Quantity Unit: STK