Product Description: Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].
Applications: Cancer-programmed cell death
Formula: C4H4O4
References: [1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8./[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31./[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072.
CAS Number: 110-17-8
Molecular Weight: 116.07
Compound Purity: 99.49
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 11.11 mg/mL (ultrasonic)
Target: Endogenous Metabolite;NF-κB;p38 MAPK
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