Product Description: Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities[1][2].
Applications: COVID-19-immunoregulation
Formula: C42H72O14
References: [1]Ma J, et, al. Gypenoside L Inhibits Proliferation of Liver and Esophageal Cancer Cells by Inducing Senescence. Molecules. 2019 Mar 18;24(6):1054./[2]Shen CY, et, al. Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response. J Agric Food Chem. 2018 Oct 31;66(43):11337-11346.
CAS Number: 94987-09-4
Molecular Weight: 801.01
Compound Purity: 99.55
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: ERK;NF-κB;p38 MAPK