Formulation: A solid
Formal Name: 4-[2-(acetyloxy)ethyl]-1,2-benzenediol
Purity: ≥98%
Formula Markup: C10H12O4
Formula Weight: 196,2
Shelf life (days): 1460
CAS Number: 69039-02-7
Notes: Hydroxytyrosol acetate is a polyphenol that has been found in O. europaea and has diverse biological activities.{68187,66863,66864,66865} It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 1.73 µM).{68187} Hydroxytyrosol acetate is active against V. parahaemolyticus (MIC = 39 µg/ml).{66863} It inhibits LPS-induced increases in nitric oxide (NO), inducible nitric oxide synthase (iNOS), and COX-2 levels in isolated mouse peritoneal macrophages when used at concentrations of 50 or 100 µM.{68187} Hydroxytyrosol acetate (1-100 µM) inhibits hypoxia- and reoxygenation-induced lactate dehydrogenase (LDH) release in isolated rat brain slices.{66864} Dietary administration of hydroxytyrosol acetate (0.05%) inhibits paw swelling, joint synovial hyperplasia, and cartilage erosion in a mouse model of collagen II-induced rheumatoid arthritis.{66865} It decreases serum levels of IgG1, IgG2a, matrix metalloproteinase-3 (MMP-3), and cartilage oligomeric matrix protein (COMP), as well as levels of TNF-α, IL-1β, IFN-γ, IL-6, IL-17a, and prostaglandin E2 (PGE2; Item No. 14010) in hind paw joint homogenates, in the same model.
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