Product Description: Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
Applications: Cancer-programmed cell death
Formula: C9H9NO
References: [1]Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37(5):506-514./[2]Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36(5):3919-30./[3]Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364(6441). pii: eaau0159.
CAS Number: 700-06-1
Molecular Weight: 147.17
Compound Purity: 98.87
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Aryl Hydrocarbon Receptor;E1/E2/E3 Enzyme;Endogenous Metabolite;NF-κB
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