Product Description: Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
Applications: Cancer-programmed cell death
Formula: C8H5NO2
References: [1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51(2), 656–659./[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47(3):216-24./[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79(1-2):35-40.
CAS Number: 91-56-5
Molecular Weight: 147.13
Compound Purity: 99.93
Research Area: Cancer; Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 1 mg/mL (ultrasonic)
Target: Apoptosis;Monoamine Oxidase
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