Product Description: Isosilybin B, a flavonolignan isolated from Silybum marianum, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation[1][2].
Applications: Cancer-programmed cell death
Formula: C25H22O10
References: [1]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42./[2]Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.
CAS Number: 142796-22-3
Molecular Weight: 482.44
Compound Purity: 99.32
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Androgen Receptor;Apoptosis
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