Product Description: Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].
Applications: Metabolism-sugar/lipid metabolism
Formula: C5H6O4
References: [1]Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128(9):3794-3805./[2]Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40(3):455-464./[3]Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53(5):499-511./[4]Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. /[5]Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11(1):18173.
CAS Number: 97-65-4
Molecular Weight: 130.10
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Solubility: H2O : 27.78 mg/mL (ultrasonic)
Target: Endogenous Metabolite;Ferroptosis
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