Product Description: Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].
Applications: COVID-19-immunoregulation
Formula: C36H45BrN4O6
References: [1]Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87./[2]Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.
CAS Number: 102396-24-7
Molecular Weight: 709.67
Compound Purity: 99.0
Research Area: Cancer; Infection
Solubility: DMSO : 10 mg/mL (ultrasonic;warming)
Target: Arp2/3 Complex;Fungal
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