Product Description: Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C10H6O3
References: [1]Zmantar T, et al. Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity. Microb Pathog. 2016 Dec;101:44-49./[2]Ji YB, et al. Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 2011 Jan;63(1-2):69-78./[3]Peng X, et al. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun. 2015 Jul 3;462(3):245-50.
CAS Number: 481-39-0
Molecular Weight: 174.16
Compound Purity: 99.88
Research Area: Cancer; Infection; Inflammation/Immunology
Solubility: DMSO : 50 mg/mL (ultrasonic)/Ethanol : 10 mg/mL (ultrasonic)
Target: Apoptosis;Bacterial;NF-κB;Toll-like Receptor (TLR)
English
Deutsch
