Product Description: Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity[1][2][3].
Applications: Cancer-programmed cell death
Formula: C15H14O3
References: [1]Raphael S Peres, et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19(1):47./[2]Masayo Maeda, et al. Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):232-8./[3]Iasmin Aparecida Cunha Araújo, et al. Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Exp Parasitol. 2019 Apr:199:67-73.
CAS Number: 84-79-7
Molecular Weight: 242.27
Compound Purity: 99.06
Research Area: Cancer; Infection; Inflammation/Immunology
Solubility: DMSO : 66.67 mg/mL (ultrasonic)
Target: Dihydroorotate Dehydrogenase;DNA/RNA Synthesis;Parasite
English
Deutsch
