Product Description: Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C20H22O4
References: [1]Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32.
CAS Number: 51020-86-1
Molecular Weight: 326.39
Compound Purity: 98.48
Research Area: Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : ≥ 50 mg/mL/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: COX;Prostaglandin Receptor;TNF Receptor
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