Product Description: Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C5H4N2O4Zn0.5
References: [1]Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids./[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15./[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21.
CAS Number: 68399-76-8
Molecular Weight: 188.79
Compound Purity: 98.0
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite;Nucleoside Antimetabolite/Analog
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