Product Description: Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].
Applications: Cancer-programmed cell death
Formula: C37H44ClNO6
References: [1]Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5)./[2]Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.
CAS Number: 12627-35-9
Molecular Weight: 634.20
Compound Purity: 99.0
Research Area: Cancer; Neurological Disease
Solubility: 10 mM in DMSO
Target: Potassium Channel
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