Product Description: Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].
Applications: Cancer-programmed cell death
Formula: C28H30O9
References: [1]Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341./[2]Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36(4):517-527.
CAS Number: 23133-56-4
Molecular Weight: 510.53
Compound Purity: 96.90
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Autophagy
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