Product Description: Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
Applications: Neuroscience-Neuromodulation
Formula: C11H17ClN2O2
Citations: Brain Res. 2023 Apr 29;148382./Brain Sci. 2023, 13(2), 262./Cell Mol Neurobiol. 2020 Oct 15. /Epilepsy Res. 2018 May;142:45-52. /Exp Eye Res. 2024 Jul 16:110008./Food Chem. 30 November 2022, 133593./Immunity. 2022 Jul 12;S1074-7613(22)00291-6./Int Immunopharmacol. 2022 Aug 22;111:109152./Int Immunopharmacol. 2024 Jan 5:128:111485./J Mol Neurosci. 2020 Nov;70(11):1858-1870./Neuropharmacology. 2017 May 1;117:238-248./Neuroscience. 2021 Feb 10;455:212-222./Research Square Preprint. 2021 Aug./BMC Immunol. 2024 Feb 12;25(1):16./Cell Rep. 2023 Apr 30;42(5):112456./Int J Mol Sci. 2023 Apr 12;24(8):7171./Int J Mol Sci. 2023 Apr 16, 24(8), 7356./Life Sci. 2022 Nov 1;308:120942./Mol Immunol. 2024 Jun 19:172:68-75./Neurochem Int. 2024 Jan 28:174:105677./Prog Neurobiol. 2022 Aug 2;102335./Research Square Preprint. 2023 Apr 13./Research Square Print. December 16th, 2022.
References: [1]Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93./[2]Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11./[3]Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32./[4]Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52.
CAS Number: 54-71-7
Molecular Weight: 244.72
Compound Purity: 99.98
Research Area: Neurological Disease; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : ≥ 37 mg/mL
Target: mAChR
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