Product Description: Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC50s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model[1].
Applications: Cancer-programmed cell death
Formula: C18H14N2O2
References: [1]Kamei H, et al., Piperafizines A and B, potentiators of cytotoxicity of vincristine. J Antibiot (Tokyo). 1990 Aug;43(8):1018-20.
CAS Number: 74720-33-5
Molecular Weight: 290.32
Research Area: Cancer
Target: Others