Product Description: Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
Applications: Cancer-Kinase/protease
Formula: C44H70O16
References: [1]Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33./[2]Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486./[3]He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.
CAS Number: 50773-41-6
Molecular Weight: 855.02
Compound Purity: 99.89
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic)
Target: Akt;Apoptosis;Autophagy;JNK;mTOR;PDK-1
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