Product Description: Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.
Applications: Neuroscience-Neuromodulation
Formula: C21H27ClN2O3
References: [1]Perry BD, et al. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-4./[2]De Vos H, et al. [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. Eur J Pharmacol. 1991 May 25;207(1):1-8./[3]Wainscott DB, et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24./[4]Neylon CB, et al. [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species. Br J Pharmacol. 1985 Jun;85(2):349-59.
CAS Number: 6211-32-1
Molecular Weight: 390.90
Compound Purity: 99.95
Research Area: Neurological Disease; Endocrinology
Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 80°C)/H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Adrenergic Receptor
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