Product Description: Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4].
Applications: Cancer-programmed cell death
Formula: N/A
References: [1]Sung-Hyun Kim, et al.Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells. Oncol Rep. 2019 Nov;42(5):1904-1914./[2]Mina Khoshnoodi, et al. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015 May;53(5):739-45./[3]Féher J, et al. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7./[4]Anna Maria Sardanelli, et al. SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome. Molecules 2021, 26(5), 1409.
CAS Number: 65666-07-1
Molecular Weight: N/A
Compound Purity: 80.0
Research Area: Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: SARS-CoV
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