Product Description: Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C9H9N
References: [1]Kurata K, et al. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019 Mar 19;510(4):649-655./[2]Zgarbová E, et al. Skatole: A thin red line between its benefits and toxicity. Biochimie. 2023 May;208:1-12./[3]Li RL, et al. Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs. Int J Biol Sci. 2024 Jan 1;20(2):680-700.
CAS Number: 83-34-1
Molecular Weight: 131.17
Compound Purity: 99.99
Research Area: Others
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Apoptosis;Aryl Hydrocarbon Receptor;Endogenous Metabolite;p38 MAPK