Tauro-β-muricholic acid, CAS 25696-60-0

Product Description: Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

Formula: C26H45NO7S

References: [1]Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35./[2]Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424(4):758-64.

CAS Number: 25696-60-0

Molecular Weight: 515.70

Research Area: Cancer; Metabolic Disease

Solubility: 10 mM in DMSO

Target: Apoptosis;FXR

• SKU: MEXHY-N9933-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N9933-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK