Product Description: Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].
Applications: COVID-19-immunoregulation
Formula: C30H26O4
References: [1]Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795./[2]Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.
CAS Number: 24449-39-6
Molecular Weight: 450.53
Compound Purity: 98.32
Research Area: Cancer; Infection
Solubility: 10 mM in DMSO
Target: Farnesyl Transferase;Parasite
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