Product Description: TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis[1][2].
Formula: C39H60O11
References: [1]Ueda JY, et al. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo). 2010 Oct;63(10):627-9./[2]Molloy EM, et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem. 2016 Dec 15;24(24):6276-6290.
CAS Number: 1314486-37-7
Molecular Weight: 704.89
Research Area: Infection; Endocrinology; Inflammation/Immunology
Target: Antibiotic;Bacterial;Proton Pump
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