Tubulysin B, CAS 205304-87-6

Product Description: Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Applications: Cancer-programmed cell death

Formula: C42H63N5O10S

References: [1]Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81./[2]Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.

CAS Number: 205304-87-6

Molecular Weight: 830.04

Compound Purity: 99.88

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Microtubule/Tubulin

• SKU: MEXHY-N1243-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-N1243-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK