Product Description: Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
Applications: COVID-19-anti-virus
Formula: C9H12N2Na2O12P2
References: [1]Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370./[2]Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46./[3]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89./[4]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.
CAS Number: 27821-45-0
Molecular Weight: 448.12
Compound Purity: 99.0
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : < 1 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: DNA/RNA Synthesis;Endogenous Metabolite;P2Y Receptor
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