Product Description: Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C9H14N2O12P2.xNa
References: [1]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89./[2]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.
CAS Number: 21931-53-3
Molecular Weight: N/A
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: DNA/RNA Synthesis;Endogenous Metabolite;P2Y Receptor
English
Deutsch
