Product Description: Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice[1].
Formula: C7H12N2O3
References: [1]Yamato M, et al., Isolation and properties of valanimycin, a new azoxy antibiotic. J Antibiot (Tokyo). 1986 Feb;39(2):184-91./[2]Yamato M, et al., Valanimycin acts on DNA in bacterial cells. J Antibiot (Tokyo). 1987 Apr;40(4):558-60.
CAS Number: 101961-60-8
Molecular Weight: 172.18
Research Area: Cancer; Infection
Target: Antibiotic;Bacterial