Product Description: Waldiomycin is an antibiotic found in Streptomyces sp. MK844-mF10 that has inhibitory effects on low GC-content Gram-positive bacteria. Waldiomycin inhibits the activity of WalK kinase by targeting its ATP-binding domain, thereby blocking the WalK/WalR signal transduction system, which plays a role in cell growth and division[1][2].
Applications: COVID-19-immunoregulation
Formula: C38H38O13
References: [1]Igarashi, et al. Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10. The Journal of antibiotics 66.8 (2013): 459-464./[2]Ishikawa, et al. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. The Journal of Antibiotics (2024): 1-11.
CAS Number: 1342200-33-2
Molecular Weight: 702.70
Research Area: Infection
Target: Antibiotic
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