12R-LOX-IN-2, CAS 3026677-37-9

Product Description: 12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].

Applications: COVID-19-anti-virus

Formula: C19H13NO

References: [1]Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.. .

CAS Number: 3026677-37-9

Molecular Weight: 271.31

Compound Purity: 99.85

Research Area: Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis;Lipoxygenase

• SKU: MEXHY-155244-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155244-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK