(1R,3R)-RSL3, CAS 1219810-15-7

Product Description: (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].

Formula: C23H21ClN2O5

References: [1]Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.

CAS Number: 1219810-15-7

Molecular Weight: 440.88

Compound Purity: 99.52

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-100218C-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100218C-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK