Product Description: 2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism)[1][2].
Formula: C10H14N5O7P.xH2O.2Na
References: [1]Petroselli G, Dántola M L, Cabrerizo F M, et al. Oxidation of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism[J]. Journal of the American Chemical Society, 2008, 130(10): 3001-3011./[2]Song B, Sigel H. Metal Ion-Coordinating Properties of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate (dGMP2-) 1 in Aqueous Solution. Quantification of Macrochelate Formation[J]. Inorganic Chemistry, 1998, 37(8): 2066-2069.
CAS Number: 146877-98-7
Molecular Weight: N/A
Research Area: Others
Solubility: 10 mM in DMSO
Target: DNA/RNA Synthesis
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