5-Octyl-α-ketoglutarate, CAS 1616344-00-3

Product Description: 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1].

Formula: C13H22O5

References: [1]Chirackal S, et al. Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide[J]. Blood, 2019, 134: 4410.

CAS Number: 1616344-00-3

Molecular Weight: 258.31

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-145452-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-145452-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK