Aβ42-IN-5

Product Description: Aβ42-IN-5 (Compound 0152) is an oral active amyloid precursor protein (APP) degrader that can reduce Aβ42 in Alzheimer's disease iPSC neurons. Aβ42-IN-5 can bind CAPRIN1 and APP and enhance the protein-protein interaction[1].

Formula: C20H20N4O4S

References: [1]Jung S, Jaiswal N, Rai R K, et al. Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer iPSC-derived neurons[J]. bioRxiv, 2023: 2023.12. 29.573648.

Molecular Weight: 412.46

Compound Purity: 98.35

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Amyloid-β

• SKU: MEXHY-161110-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161110-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK