Product Description: AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease[1].
Applications: Neuroscience-Neurodegeneration
Formula: C18H17F3O
References: [1]McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55./[2]Jian-Nong Ma, et al. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7(9):1180-7.
CAS Number: 1421854-16-1
Molecular Weight: 306.32
Compound Purity: 99.61
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Estrogen Receptor/ERR
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